Tissue Regeneration

Self-Regeneration of Three Types of Tissues

 * The epithelia can regenerate spontaneously
 * Ex. the epidermis in skin
 * The basement membrane regenerates spontaneously on the connective tissue
 * The connective tissue does not regenerate spontaneously
 * Ex. dermis in skin

Regeneration vs Repair

 * Microscopic defects can regenerate with or without being treated by pharmaceuticals, vitamins, hormones, and antibiotics
 * Organ-scale defects (large defects, mm or cm scale) caused by disease or by an acute or chronic insult can not regenerate
 * Adult mammals do not typically exhibit spontaneous regeneration after severe organ injuries
 * Adult mammalsd undergo REPAIR following severe organ injuries
 * Closure of the wound by cell-mediated contraction and scar tissue formation
 * Prevents infection from viruses and bacteria
 * REGENERATION is characterized by the synthesis of a physiological (normal, functional) replacement tissue in the wound site that is structurally and functionally similar to the original tissue