Mechanical Loading


 * Tissues and organs in the body are subjected to complex biomechanical environments
 * Mechanical stimulation can modulate the activity of cells within engineered tissues cultured in vitro to develop tissues resembling the mechanical properties, cellular distribution, and orientation as target tissues

Engineered Arteries-Pulsatile Radial Strains

 * Arteries transport blood in the body under high pulsatile pressures (80-120 mmHg), inducing cyclic radial distensions ranging up to 10%
 * Pulsatile flow enhanced the structure and mechanical integrity of engineered vessels as compared to nonpulsed vessels